Gus's Drug Empire serves as the main focus of Season 3 and Season 4 of Breaking Bad, as well as much of Better Call Saul.

It starts as the most powerful branch of the Juárez Cartel, as run by Gustavo Fring. However, Fring has the Cartel beheaded to eliminate all competition, making his Drug Empire the biggest crime syndicate in the southwest. It's soon destroyed and replaced by Walt's Drug Empire.